Product Information

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Exclzyme® 2AF is a concentrated systemic enzyme blend of several powerful protease enzymes. These enzymes are not derived from an animal source and, as such, are suitable for vegetarians. EXCLZYME® 2AF contains a proprietary blend of fungal proteases, Bromelain, Papain and Peptizyme SP® EN. Peptizyme SP® EN is an enteric coated serrapeptase derived from Serratia spp. E-1. Peptizyme SP® EN possesses greater caseinolytic (fibrinolytic) activity than any other known alkaline or neutral protease. Its fibrinolytic activity is greater even than the very expensive trypsin and chymotrypsin.

Exclzyme® 2AF also contains the enzymes Amylase and Lipase. The addition of a natural gooseberry called Amla and Rutin provide additional support to the enzymatic activity.

BACKGROUND

Enzymes are ubiquitous in living organisms, and perform a wide variety of regulatory and functional roles in cellular processes. Proteases are no exception, and are particularly effective in repair and healing processes. While proteases are often used to improve digestion and blood circulation, research has shown the blend in Exclzyme® EN to be useful in reducing pain and inflammation in joints.1-5 In addition, this same research demonstrates that Exclzyme® EN also possesses significant activity in the inhibition of C-Reactive Protein.1

FEATURES

  • Proteases digest and deactivate proteins that block normal healing
  • Inactivate bradykinin peptides (reduce pain and prevent progression);
  • Reduce viscosity of extracellular fluid (reduce edema);
  • Reduce blood viscosity by maintaining healthy fibrin levels
  • Induce molecular debridement (removal of necrotic tissue and proteins, reduce edema);

RESEARCH

A University of Maine clinical double-blind study with Exclzym® was conducted in 2003. The results clearly demonstrate its efficacy for most symptoms associated with joint problems including fatigue, soreness, discomfort and swelling.1

Further, Exclzyme® showed a significant inhibition of C-Reactive Protein, a recognized marker for inflammation. This trial supports the product’s efficacy with both subjective and objective end-points.1
There appears to be no drawbacks to this product with respect to safety as determined by this trial. Furthermore, the active ingredients have a long medical history of use and are generally recognized as safe (GRAS) by the USDA.

REFERENCES

1. Blum, J., et al. "Randomized, Double-Blind Clinical Trial for Healthy Joint Function: A Study to Assess the Efficacy of a Joint Blend: Joint and Muscle Pain, Fatigue, Soreness, and Discomfort."
University of Maine, Dept Food Sciences & Human Nutrition 2003 (on file)

2. Christie RB: The medical uses of proteolytic enzymes. Topics in Enzyme and Fermentation. Biotechnology 1980; 4:25.

3. Kleine MW: Introduction to systematic enzyme therapy and results of experimental trials. Sports, Medicine and Health 1990, 1131.

4. Trickett P., Proteolytic enzymes in the treatment of athletic injuries. Appl Ther 1964: 6:647.

5. Baumuller M.: Therapy of ankle distortions with enzymes - results from double-blind clinical trial. Sports, Medicine,& Health 1990, 1137.

PROPERTIES

Appearance: Pale yellow, free flowing powder with granules
Solubility: Soluble in water, not in ethanol
Moisture: Not more than 7.0%
Enzymes: Proteases, Peptizyme SP® EN, Papain, Bromelain, Amylase and Lipase
Other Ingredients Amla, Rutin
E. Coli Negative
Salmonella Negative
TPC less than 3000 CFU/gm

Recommended Use: Optimum dosage must be determined based upon individual need. The general recommended dosage is 250 to 350 mg per capsule. Take one to two capsules in the morning and again at night with a full glass of water or as directed by your healthcare professional.

STORE IN A COOL, DRY PLACE. KEEP OUT OF THE REACH OF CHILDREN.

Caution: If you are taking anti-coagulants such as Coumadin or other warfarin products, do not take this product without consulting your physician. If you are pregnant or nursing, consult your healthcare professional before using this or any dietary supplement.

STORAGE and PACKAGING: Exclzyme® should not lose more than 10 - 20% activity in 12 months from date of manufacture if stored in a cool, dry place. Optimum storage is 4-10oC and low RH. It is packed in 25 kg cartons and sealed in double polybags.

The information contained in this product sheet is, to the best of our knowledge true and accurate. Recommendations or suggestions made herein are without guarantee since the conditions of use and storage are beyond our control. Specialty Enzymes and BiotechnologiesTM does not guarantee that the product can be used as described herein without prior positive testing.

Exclzyme® EN is a Registered Trademark of Specialty Enzymes and Biochemicals Co.

 

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